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CRITICAL CARE AND TRAUMA

Acupuncture Stimulation of ST36 (Zusanli) Attenuates Acute Renal but Not Hepatic Injury in Lipopolysaccharide-Stimulated Rats

Chin-Liang Huang, MD, PhD^*, Pei-Shan Tsai, PhD, Tao-Yeuan Wang, MD, Li-Ping Yan, PhD, Heng-Ze Xu, MD^*, and Chun-Jen Huang, MD, PhD^||¶#

From the *Acupuncture and Moxibustion Institute, Nanjing University of Traditional Chinese Medicine, Nanjing, China; Graduate Institute of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan; Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan; Institute of Molecular Biology, Nanjing University of Traditional Chinese Medicine, Nanjing, China; ||Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan; ¶Mackay Medicine, Management, and Nursing College, Taipei, Taiwan; and #Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan.

Address correspondence and reprint requests to Dr. Chun-Jen Huang, Department of Anesthesiology, Mackay Memorial Hospital, 92 Sec. 2 Chung San N. Rd., Taipei 10449, Taiwan. Address e-mail to sean{at}ms2.mmh.org.tw.

BACKGROUND: We sought to determine the effects of ST36 acupuncture on sepsis-induced kidney and liver injuries.

METHODS: A total of 120 rats were randomized into 10 groups: 1) lipopolysaccharide (LPS), 2) normal saline (N/S), 3) LPS + ST36, 4) ST36, 5) LPS + P-ST36, 6) P-ST36, 7) LPS + Sham, 8) Sham, 9) LPS + P-Sham, and 10) P-Sham groups. Rats in the LPS + ST36, ST36, LPS +Sham, and Sham groups received ST36 (designated as "ST36") or a nonacupoint (designated as "Sham") acupuncture for 30 min followed by LPS or N/S injection. Rats in the LPS + P-ST36, P-ST36, LPS + P-Sham, and P-Sham groups received LPS or N/S injection for 3 h followed by a 30 min of ST36 or a "nonacupoint" acupuncture. Rats were killed at 6 h after LPS injection.

RESULTS: LPS caused prominent kidney and liver injuries. The renal and hepatic nitric oxide (NO) concentrations and inducible NO synthase (iNOS) expression were also increased by LPS. ST36 acupuncture pretreatment significantly attenuated the LPS-induced kidney injury and the increases in renal NO concentration and iNOS expression. However, ST36 acupuncture pretreatment did not affect the LPS-induced liver injury and increases in hepatic NO concentration or iNOS expression. Furthermore, ST36 acupuncture performed after LPS did not affect the LPS-induced organ injuries or increases in NO concentration and iNOS expression.

CONCLUSIONS: ST36 acupuncture pretreatment significantly attenuated sepsis-induced kidney, but not liver, injury in rats, whereas ST36 acupuncture performed after sepsis induction had no protective effects against sepsis-induced organ injuries.

Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins with the assistance of Stanford University Libraries' HighWire Press®. Copyright 2006 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999